The Great North Air Ambulance Service (GNAAS) was called at 8.30am today to the A68 at Houghton Bank, near Darlington, where a car had left the road and hit a tree.
The GNAAS doctor-led aircrew worked alongside paramedics from the North East Ambulance Service and local fire crews.
The man, believed to be in his 20s and from West Auckland, had sustained serious leg, arm, chest and abdominal injuries in the collision.
He was treated on scene by the GNAAS aircrew before being flown to James Cook University Hospital, Middlesbrough.
The flight to hospital took just eight minutes, this same journey by road would have taken around 30 minutes.
He arrived at hospital in a stable condition.